Scientists were able to reduce tablets 2.5 times without loss of dosage medication


Engineers have developed a new packaging technology of hydrophobic drugs in a tablet, which allows to increase their concentration by 2.5 times.

No one likes to swallow big pills entirely, and some people simply cannot do this, which reduces the effectiveness of their action. Now researchers from the Massachusetts Technological Institute have found a way to reduce the size of the tablet almost 2.5 times, placing the standard amount of medication in it. It is designed specifically for drugs, with the active components insoluble in water, which now account for about 60% of all drugs.

When creating such tablets at present, the active substances are crushed to the size of nanocrystals so that the human body is better absorbed, and then mixed with the auxiliary substances to stabilize and control the release. However, the grinding process requires the cost of time and energy and can change the properties of active components.

The MIT team went to another way, and dissolved the active drug component from cholesterol (fenofibrate) in oil called anisole. Further, the researchers mixed this mixture with a popular methylcellulose auxiliary substance dissolved in water. Then the resulting nanoemulsion was drilled in hot water, as a result of which they instantly harden and turned into a gel.

After drying and forming, scientists received pills with fenofibrate nanocrystals, evenly distributed in the methylcellulose matrix. The analysis showed that an active ingredient accounts for 60% of their mass, which significantly exceeds the indicator of drugs produced now, equal to about 25%. This allows you to reduce the size of the tablet, saving the dosage.

Previously, we also reported the development of technology that allows you to deliver

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